Resumen

MERCADO, Ulises. Rheumatoid arthritis, autoantibodies, and PAD enzymes. Med. interna Méx. [online]. 2019, vol.35, n.3, pp.425-428.  Epub 05-Mar-2021. ISSN 0186-4866.  https://doi.org/10.24245/mim.v35i3.2500.

Rheumatoid arthritis is a systemic, inflammatory disease characterized by chronic synovitis and presence of autoantibodies. Risk factors include HLA-DRβ1 genes, periodontal disease and smoking. At least 5 different autoantibodies to autoantigens are implicated in the pathogenesis of this disorder: 1) rheumatoid factor; 2) autoantibodies directed against citrullinated peptides/proteins (ACPA); 3) anti-carbamilated protein antibody (anti-carP); 4) anti-peptidylarginine deiminase antibody (anti-PAD2/4), and 5) anti-citrullinated fibrinogen antibody. Patients with rheumatoid arthritis have been divided into two disease subsets: ACPA-positive rheumatoid arthritis and ACPA- negative rheumatoid arthritis. ACPA-positive rheumatoid arthritis is associated with HLA-DRβ1 shared epitope alleles and is recognized by antigen-specific T cells and B cells.

Palabras llave : Rheumatoid arthritis; Autoantibodies to autoantigens; Peptidylarginine deiminase.

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