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Gaceta médica de México
versión On-line ISSN 2696-1288versión impresa ISSN 0016-3813
Resumen
MENDOZA-PINTO, Claudia et al. Insulin resistance metabolomic profile in non-diabetic women with systemic lupus erythematosus. Gac. Méd. Méx [online]. 2021, vol.157, n.6, pp.613-617. Epub 13-Dic-2021. ISSN 2696-1288. https://doi.org/10.24875/gmm.21000218.
Introduction:
Patients with systemic lupus erythematosus (SLE) have a higher prevalence of insulin resistance (IR) and metabolic syndrome (MetS) than controls.
Objective:
To evaluate IR in non-diabetic women with SLE by means of biomarkers using high-throughput metabolomic techniques.
Methods:
Cross-sectional study in patients with SLE. A metabolomic approach was employed using ultra-high performance liquid chromatography coupled with high-resolution mass spectrometry. MetS was evaluated according to NCEP-ATP III criteria.
Results:
Seventy patients with SLE were included, out of whom 45 (64.2 %) and 27 (38.5 %) had IR and MetS, respectively. Patients with IR had a higher body mass index and hypertension more often than those without IR. Chronic damage and disease activity were not related to IR. A Quantose-IR score ≥ 63 was more common in patients with MetS (81.5 vs. 53.5 %; p = 0.02). Quantose-IR score was also correlated with the number of criteria for MetS (r: 0.35; p = 0.003).
Conclusions:
In non-diabetic women with SLE, the prevalence of IR based on Quantose-IR score was 64.2 %.
Palabras llave : Systemic lupus erythematosus; Insulin resistance; Metabolomics.