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Revista mexicana de fitopatología
versión On-line ISSN 2007-8080versión impresa ISSN 0185-3309
Resumen
TAPIA-QUIROS, Paulina; MARTINEZ-TELLEZ, Miguel Ángel; AVILA-QUEZADA, Graciela Dolores y VARGAS-ARISPURO, Irasema. Inhibition of fungal endo-1,3- β-glucanase by phenols isolated from Turnera diffusa: an alternative for conventional antifungals. Rev. mex. fitopatol [online]. 2020, vol.38, n.1, pp.160-169. Epub 27-Nov-2020. ISSN 2007-8080. https://doi.org/10.18781/r.mex.fit.1911-3.
The fungal enzyme endo-1,3-β-glucanase plays a physiological role in morphogenetic processes during development and differentiation in some fungi. Additionally, this enzyme has been implicated in fungal attack during fungus-plant interactions. Therefore, fungal endo-1,3-β-glucanase has been used as a target site for the directed search of antifungal compounds. Using the biodirected isolation of bioactive compounds, two phenolic compounds were isolated from Turnera diffusa stems that inhibited the activity of fungal endo-1,3-β-glucanase. The identified compounds apigenin and luteolin inhibited the activity of the enzyme by 90 and 60%, respectively. Consistent with the inhibitory effect of the fungal enzyme, apigenin at millimolar concentrations was able to completely inhibit the spore germination of Botrytis cinerea. It is inferred that the antifungal action of apigenin is due to its ability to inhibit the fungal endo-1,3-β-glucanase enzyme.
Palabras llave : antifungal; apigenin; luteolin; phenol acids.