ESCALONA RAYO, Oscar    QUINTANAR GUERRERO, David. Polymeric nanogels: a new alternative for drug delivery. []. , 45, 3, pp.17-38. ISSN 1870-0195.

The nanogels are cross-linked polymer particles of submicron size with unique properties like high water content, three-dimensional structure, biocompatibility and the most important, its swelling degree which permits drug release by external environmental conditions to the nanogel like for example; the temperature and pH. In this review we analyze the potential, advantages and disadvantages of nanogels as drug delivery systems and macromolecules, in particular to achieve a specific location in tissues or target cells. Also we will focus on describe the two synthetic routes and preparation of nanogels: cross-linking of polymers and cross-linking polymerization monomers. Finally, we review the most widely used techniques for its characterization: light scattering, viscometry microscopy and spectroscopy.

: nanogels; swelling; drug delivery systems; cross-linked; polymerization.

        · |     · |     · ( pdf )